Research Imaging Centre
Centre for Addiction and Mental Health
250 College Street
Toronto, Ontario M5T 1R8
Dr. Jeffrey Meyer is a Canada Research Chair in the neurochemistry of major depression. He is also the head of the Neurochemical Imaging Program in Mood and Anxiety disorders at the CAMH Research Imaging Centre and a full professor at the University of Toronto, Department of Psychiatry. He is the first psychiatrist to receive the Royal College Medal Award in Medicine (in the 60 year history of the award) for his contributions in understanding monoamine dysregulation during major depressive disorder. Dr. Meyer has also received the AE Bennett award, and the Dewan award for outstanding contributions to psychiatric research.
Dr. Meyer discovered that monoamine oxidase A binding is elevated during major depressive episodes, prior to recurrence of major depressive episodes and during high risk states for major depressive episodes such as early postpartum. He also discovered that serotonin transporter binding in increased in the winter relative to summer. He has conducted and published leading antidepressant occupancy studies for serotonin and dopamine transporters, 5-HT2A receptors and monoamine oxidase. His work established the therapeutic occupancy for selective serotonin reuptake inhibitors. His publications include more than 75 peer-reviewed papers, 50
per cent as first/senior author. He is the lead/senior author of seven papers in
JAMA Psychiatry/Archives of General Psychiatry and seven papers in the American
Journal of Psychiatry.
Areas of Research
Dr. Meyer is currently extending the range of mood disorder research at CAMH by directing projects investigating postpartum depression, seasonal affective disorder, biological predictors of recurrence and treatment resistance, as well as antidepressant occupancy for novel target sites. Dr. Meyer is also running an active program investigating markers of neuroinflammation in mood disorders.
View Dr. Meyer's publications on PubMed.