Skip Ribbon Commands
Skip to main content
Navigate Up

Dr. Brian F. O'Dowd

Molecular Pharmacology
Centre for Addiction and Mental Health
University of Toronto
Medical Sciences Building, room 4353
1 King’s College Circle
Toronto, Ontario    M5S 1A8
(416) 978-7579

Dr. Brian O'Dowd is a Molecular Pharmacologist and Neuroscientist and Co-Section Head of Molecular Pharmacology in the Campbell Family Mental Health Research Institute at CAMH. He is also a Professor of Pharmacology at the University of Toronto. 

Areas of Research
Over the past decade, Dr. O'Dowd's laboratory has  discovered many new G protein coupled receptors (GPCRs).  These proteins are involved in physiological functions in brain, but only a few of the total 367 GPCRs have been the targets for drug development.  They represent a substantial resource and constitute a highly relevant group of protein targets for novel drug discovery. 

Dr. O'Dowd and his team have also invented an entirely novel method for the identification of drugs that activate or block these receptors. The novel strategy they employed involves the translocation of the GPCR with a specific genetic modification from the cell surface with no recycling of the protein back to the cell surface.  Interaction of the modified receptor with a drug prevents the translocation away from the cell surface and is measured as receptor retained on the cell surface.  This assay will speed the process by which new drugs can be recognized and pave the way for new generations of therapeutically active drugs, with potential medical and quality-of-life implications for all Canadians.

View Dr. O'Dowd's publications on PubMed.


CAMH Switchboard 416-535-8501
CAMH General Information Toronto: 416-595-6111 Toll Free: 1-800-463-6273
Connex Ontario Help Lines
Queen St.
1001 Queen St. W
Toronto, ON
M6J 1H4
Russell St.
33 Russell St.
Toronto, ON
M5S 2S1
College St.
250 College St.
Toronto, ON
M5T 1R8
Ten offices across Ontario