Centre for Addiction & Mental Health
250 College Street, Room 711
(416) 535-8501 ext. 4010
Dr. Wong is Scientist in the Campbell Family Mental Health Research Institute, and Staff Psychiatrist in the Schizophrenia Division at the Centre for Addiction and Mental Health. He is Professor of Pharmacology at the University of Toronto.
Areas of Research
Dr. Wong attended medical school at the University of Toronto, where he completed specialty training in psychiatry and a PhD in neurobiology. His lab uses preclinical models to investigate genetic, cellular and developmental mechanisms underlying psychiatric symptoms, and his area of clinical expertise is schizophrenia.
Selected list of publications:
Zawadzki J, Woodward R, Sokolowski HM, Boon HS, Wong AH, Menon M: Cognitive factors associated with subclinical delusional ideation in the general population, Psychiatry Research in press.
Wong AH, Liu F: Uncoupling the dopamine D1-D2 receptor complex: a novel target for antidepressant treatment, Clinical Pharmacology and Therapeutics 2011 Dec 28. doi: 10.1038/clpt.2011.311. [Epub ahead of print].
Asefa D, Haque FN, Wong AHC: Case Report: Anxiety and fear in a patient with meningioma compressing the left amygdala. Neurocase 2011 October 20 [Epub ahead of print].
Labrie V, Wong AH, Roder JC: Contributions of the D-serine pathway to schizophrenia, Neuropharmacology 2011 Feb 2 [Epub ahead of print].
Lee FH, Fadel MP, Preston-Maher K, Cordes SP, Clapcote SJ, Price DJ, Roder JC, Wong AHC: Disc1 point mutations in mice alter development of the cerebral cortex. The Journal of Neuroscience 2 March 2011, 31(9):3197-3206.
Lee FH, Kaidanovich-Beilin O, Roder JC, Woodgett JR, Wong AH: Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice, Schizophrenia Research 129 (2011) 74-76.
Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh G, Wong AHC, Feldcamp
LA, Virtanen C, Halfvarsson J, Tysk C, McRae A, Visscher P, Montgomery GW, Gottesman II, Martin NG, and Petronis A: DNA methylome studies in twins, Nature Genetics 2009; 41, 240 - 245.
Labrie V, Fukumura R, Rastogi A, Fick LJ, Wei W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AHC, Roder JC. Genetic inactivation of serine racemase produces behavioral phenotypes related to schizophrenia in mice. Human Molecular Genetics 2009; Vol 18 (17): 3227-3243.
Wong AHC, Trakalo J, Likhodi O, Yusuf M, Macedo A, Azevedo M-H, Klempan T, Pato MT, Honer WG, Pato CN, Van Tol HHM, Kennedy JL: Association between schizophrenia and the syntaxin 1a gene, Biological Psychiatry 2004; 56(1):24-29.
Wong AHC, Macciardi F, Klempan T, Kawczynski W, Barr CL, Lakatoo S, Wong M, Buckle C, TrakaloJ, Boffa E, Oak J, Azevado M-H, Dourado A, Coelho I, Macedo A, Vicente A, Valente J, Paz Ferreira C, Pato MT, Pato CN, Kennedy JL, Van Tol HHM: Identification of candidate genes for psychosis in rat models and possible association between schizophrenia and the 14-3-3h gene. Molecular Psychiatry 2003; 8(2): 156-166.