Investigating healthy brains with non-invasive brain stimulation

The study investigates how brain activity changes using non-invasive brain stimulation (TMS-EEG). There will be a screening appointment followed by an MRI and then multiple sessions of TMS-EEG. During TMS-EEG you will be seated with an EEG cap on your head. The cap contains sensors that will be gelled to record brain activity. Then a coil will be positioned over different areas of your brain that send small magnetic pulses. You may be asked to perform a simple task or remain relaxed.

Eligibility Criteria

You may be enrolled in the study if you are;

1. Aged 18-55
2. Are non-smokers
3. Are fluent in the English language (spoken, written and reading)
4. Are competent to consent
5. Do not meet criteria for any major neuropsychiatric disorders
6. Are right-handed

You may NOT participate in the study if you;

1. Have a cardiac pacemaker, cochlear implants, implanted electronic devices or other contraindication to MRI
2. Have a history of a medical or neurological disorder that affects the CNS (e.g. traumatic brain injury, stroke, Parkinson's disease)
3. Are pregnant
4. Have a history of seizures
5. Have a serious or unstable medical condition requiring immediate investigation or treatment
6. Are taking psychotropic medications
7. Test positive for illicit drug use on the urine screening test

What does the study involve?

• Number of contacts: 10+ in-person visits
• Compensation offered? Yes

Investigator(s): Dr. Christoph Zrenner 
Full Study Title: Precision in Space and Time: Brain State-Dependent Stimulation Using Real-Time EEG and TMS (SPACETIME)

Contact Information:
E-mail: camhbrainstudy@camh.ca

REB number: 2022-067
REB Approval Expiry Date: November 24, 2025

PLEASE NOTE:

• Research staff cannot give medical advice over the phone or via email.
• If you have specific questions regarding your health care, please contact your family physician.
• We regret that not everyone screened for a study will be eligible to participate
• For more information about other treatment options for mental illness or addiction offered by CAMH, visit www.camh.ca or call 416-535-8501.