The study uses non-invasive brain stimulation (TMS-EEG) and (MRI) to investigate how feelings of sadness vs. distraction can alter brain activity. The study involves 11 visits that include a clinical interview, screening questionnaires, MRI and 8 TMS-EEG sessions. During TMS-EEG, you will be comfortably seated wearing a fitted sensor cap that will be gelled. A coil will be positioned over difference areas of your brain and small pulses will be administered to record brain activity
Eligibility Criteria
you will be included in the study if you are:
- Age 18-65 years old;
- Diagnosed with depression without psychosis;
- Do not abuse substances such as drugs and alcohol
- Fluent in English
- Able to sign and date the informed consent form;
- Are willing to comply with all study procedures.
What does the study involve?
- Number of contacts: 10+ in-person visits
- Compensation offered? Yes
Investigator(s): Dr. Christoph Zrenner
Full Study Title: Identification of EEG and TMS-EEG Biomarkers of Dysphoria and Rumination Symptom Severity State in Major Depressive Disorder (DYSMARK)
Contact Information:
E-mail: camhbrainstudy@camh.ca
REB number: 2023-130
REB Approval Expiry Date: April 15, 2026
PLEASE NOTE:
- Research staff cannot give medical advice over the phone or via email.
- If you have specific questions regarding your health care, please contact your family physician.
- We regret that not everyone screened for a study will be eligible to participate
- For more information about other treatment options for mental illness or addiction offered by CAMH, visit www.camh.ca or call 416-535-8501.