Dr. Arash Nazeri is an Independent Scientist with the Brain Health Imaging Centre at CAMH. He earned his medical degree from Tehran University of Medical Sciences in Iran. Subsequently, he came to CAMH as a postdoctoral research fellow, where he focused on imaging-genetics, computational neuroimaging, and diffusion-weighted MRI. He then moved to the US to complete his residency training in diagnostic radiology and fellowship training in neuroradiology at Washington University in St. Louis.
At Washington University, Dr. Nazeri dedicated his efforts to identify the underlying patterns of white matter development during the early postnatal stage through the utilization of fluid-sensitive MRI sequences, unsupervised machine learning, and post-mortem histology. Additionally, he explored the applications of MR-guided focused ultrasound in altering brain fluid compartments and opening the blood-brain barrier to enhance the release of brain-derived biomarkers in both brain tumors and neurodegenerative conditions such as Alzheimer's disease. His research was generously supported by the Canadian Institutes of Health Research (CIHR), Radiological Society of North America (RSNA), and American Society of Neuroradiology (ASNR).
Areas of Research
Dr. Nazeri's research encompasses the development and utilization of neuroimaging techniques to examine the brain microstructure and neurofluid dynamics in early development and aging, as well as associated brain disorders such as neurodevelopmental disorders (e.g., autism) and neurodegenerative disorders (e.g., Alzheimer’s disease).
Publications
- Pacia C, Yuan, J, Yue Y, Leuthardt EC, Benzinger, TL, Nazeri A*, Chen H*. Focused ultrasound mediated liquid biopsy in a tauopathy mouse model. Radiology.
2023. Jan. 31, 2023. https://doi.org/10.1148/radiol.220869
- Nazeri A*, Krsnik Ž, Kostović I, Ha SM, Kopić J, Alexopoulos D, Kaplan S, Meyer D, Luby JL, Warner BB, Rogers CE, et al. Neurodevelopmental patterns of early postnatal white matter maturation represent distinct underlying microstructure and histology. Neuron. 2022 Dec 7;110(23):4015-30.
https://doi.org/10.1016/j.neuron.2022.09.020 - Nazeri A, Mulsant BH, Rajji TK, Levesque ML, Pipitone J, Stefanik L, Shahab S, Roostaei T, Wheeler AL, Chavez S, Voineskos AN. Gray matter neuritic microstructure deficits in schizophrenia and bipolar disorder. Biological Psychiatry. 2017 Nov 15;82(10):726-36. https://doi.org/10.1016/j.biopsych.2016.12.005
- Nazeri A, Chakravarty MM, Rotenberg DJ, Rajji TK, Rathi Y, Michailovich OV, Voineskos AN. Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan. Journal of Neuroscience. 2015 Jan 28;35(4):1753-62. https://doi.org/10.1523/JNEUROSCI.3979-14.2015
- Nazeri A, Chakravarty MM, Felsky D, Lobaugh NJ, Rajji TK, Mulsant BH, Voineskos AN. Alterations of superficial white matter in schizophrenia and relationship to cognitive performance. Neuropsychopharmacology. 2013 Sep;38(10):1954-62. https://doi.org/10.1038/npp.2013.93
View Dr. Nazeri’s publications on myNCBI.